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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), diabetic nerve pain, fibromyalgia, and chronic musculoskeletal pain.It is usually taken once or twice daily with or without food and can take up to 6 weeks to experience maximum benefit.
The most common side effects of duloxetine are nausea, dry mouth, constipation, sleepiness, and decreased appetite. Other side effects include anxiety, nervousness, irritability, fatigue, imbalance, sweating, hot flashes, and sexual difficulties.
Duloxetine is thought to work by inhibiting the reuptake of serotonin and norepinephrine, which leads to increased levels of these chemicals in the brain. This action is thought to improve communication between nerve cells and help relieve symptoms of depression and anxiety.
Alcohol should be avoided when taking duloxetine. Alcohol is a central nervous system depressant. This means that it can cause drowsiness, slowed thinking, and impaired motor skills. When alcohol is combined with duloxetine, these effects may be worse. Alcohol can also interfere with the way duloxetine works in the brain. For these reasons, it is generally not recommended to drink alcohol while taking duloxetine.
Yes, it is often used to treat nerve pain that isn’t responding to other medications. Duloxetine works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters that are known to be involved in pain signaling. As a result, duloxetine can help to reduce the perception of pain.
Weight gain is a rare side effect of duloxetine, occurring in less than 1% of people taking the drug. If you experience weight gain while taking duloxetine, talk to your doctor about other treatment options. Changes in diet and exercise can help to offset any weight gain caused by duloxetine.